MEDICINE
INFECTIOUS DISEASES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Mosquitoes have many stages in thier life cycle.
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The parasite are only vulnerable to atttack when outide the liver and red blood cells.
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The human immune system doesnot recognise the antigens of the parasite.
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Vaccines are repidly broken down by proteases in stomach.
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Detailed explanation-1: -Barriers to Developing a Malaria Vaccine Malaria parasites have a complex life cycle, and there is poor understanding of the complex immune response to malaria infection. Malaria parasites are also genetically complex, producing thousands of potential antigens.
Detailed explanation-2: -Researchers found evidence to suggest that the same inflammatory molecules that drive the immune response in clinical and severe malaria also prevent the body from developing protective antibodies against the parasite.
Detailed explanation-3: -However, development of a malaria vaccine is technically very challenging, compared to that of bacterial and viral vaccines. This arises from the fact that the genome of the malarial parasite (Plasmodium) is much larger and more complex than bacterial and viral genomes.
Detailed explanation-4: -To evade the human immune system and enter red blood cells, a normally active gene in the malaria parasite nucleus goes into silent state-then switches back to active state when immunity wanes.