CLINICAL MEDICINE

Detailed explanation-1: -Dopamine is a signaling molecule in the brain that is involved in motor control. Increased levels of dopamine are thought to cause chorea in Huntington’s disease patients.

Detailed explanation-2: -The most widely recognized cause of chorea is Huntington’s disease-a hereditary disorder. But, there can be many other causes, some of which are very rare. A child who got rheumatic fever after a strep throat or scarlet fever infection may show a temporary form of chorea.

Detailed explanation-3: -It is characterized by brief, abrupt, irregular, unpredictable, non-stereotyped movements. In milder cases, chorea may appear purposeful. The patient often appears fidgety and clumsy. Overall, chorea can affect various body parts, and interfere with speech, swallowing, posture and gait, and disappears in sleep.

Detailed explanation-4: -It is characterized by sudden, brief, nonrhythmic, nonrepetitive twitching of limbs with facial grimacing. There is a history of sore throat several weeks before onset of symptoms which include, involuntary movements, slurred speech, hypotonia, and difficulty holding objects, writing, eating, and dressing [6].