CLINICAL MEDICINE

Detailed explanation-1: -Parkinson’s disease is a progressive disorder that is caused by degeneration of nerve cells in the part of the brain called the substantia nigra, which controls movement. These nerve cells die or become impaired, losing the ability to produce an important chemical called dopamine.

Detailed explanation-2: -Up to 98% of all people with Parkinson’s experience slowness of movement. Bradykinesia is one of the early signs of a movement disorder such as Parkinson’s or parkinsonism. It is caused by reduced levels of dopamine in the brain and is often first noticed by family and friends.

Detailed explanation-3: -Slowness of movement is one of the main symptoms of Parkinson’s, alongside tremor and rigidity (stiffness). The medical term for slowness of movement is bradykinesia.

Detailed explanation-4: -In Parkinson’s disease, certain nerve cells (neurons) in the brain gradually break down or die. Many of the symptoms are due to a loss of neurons that produce a chemical messenger in your brain called dopamine.

Detailed explanation-5: -Pathophysiologically, tremor is linked to altered activity in not one, but two distinct circuits: the basal ganglia, which are primarily affected by dopamine depletion in Parkinson’s disease, and the cerebello-thalamo-cortical circuit, which is also involved in many other tremors.