CLINICAL MEDICINE

Detailed explanation-1: -Central nervous system (CNS) axons do not spontaneously regenerate after injury in adult mammals. In contrast, peripheral nervous system (PNS) axons readily regenerate, allowing recovery of function after peripheral nerve damage.

Detailed explanation-2: -Injured nerve cells in the central nervous system typically do not regenerate. However, this part of the nervous system can reorganize in response to an injury. This is called “plasticity.” Luckily, the brain has a lot of built-in redundancy.

Detailed explanation-3: -Mechanism of Nerve Regeneration. Cajal61 was the first to demonstrate that viable nerve fibers grow out of the proximal stump of an injured neuron about 6 hours after injury, followed about 36 hours later by growth at the axon tip.

Detailed explanation-4: -Nerves can be easily damaged in a traumatic event, but can regenerate if the soma and a small portion of the neurilemma remain. Neuroregeneration refers to the regrowth or repair of nervous tissues, cells, or cell products. Such mechanisms may include generation of new neurons, glia, axons, myelin, or synapses.

Detailed explanation-5: -During embryonic development, neurons grow processes called “axons”, by which they reach out to other neurons and ultimately make connections to them. But this ability is subsequently lost. In fact, neurons of the adult brain and the spinal cord are unable to regenerate and form new axons.