CLINICAL MEDICINE

Detailed explanation-1: -From the fourth ventricle, a portion of the CSF flows inferiorly through the central canal. Most of the CSF escapes through the median foramen of Magendie and the two lateral apertures of Luschka into the subarachnoid space (SAS).

Detailed explanation-2: -At its superolateral portions, two channels drain CSF into the surrounding neural tissue. These are called the lateral apertures, or the foramina of Luschka. Inferomedially is the median aperture or the foramen of Magendie. These apertures help spread CSF around the spinal cord and the surrounding neural structures.

Detailed explanation-3: -Exit of CSF from the fourth ventricle is directed into the dorsal spinal subarachnoid space through the foramen of Magendie and into the basal cisterns through the lateral foramina of Luschka.

Detailed explanation-4: -The CSF exits the subarachnoid space by diffusing through the walls of arachnoid granulations. The arachnoid granulations provide a valvular mechanism for the flow of CSF, which allows the inflow of CSF into the bloodstream without permitting the backflow of blood into the CSF.

Detailed explanation-5: -The foramen of Magendie, also known as median aperture, is one of the foramina in the ventricular system and links the fourth ventricle and the cisterna magna. It is one of the three sites that cerebrospinal fluid (CSF) can leave the fourth ventricle and enter the subarachnoid space.