CLINICAL MEDICINE

Detailed explanation-1: -The blood-brain barrier is the barrier between the cerebral capillary blood and the interstitial fluid of the brain. It is made up of capillary endothelial cells and basement membrane, neuroglial membrane, and glial podocytes, i.e., projections of astrocytes.

Detailed explanation-2: -The BBB is composed by brain capillary endothelial cells (ECs), with a specific phenotype located in a strong association with astrocytic endfeet processes and mesenchymal-like cells pericytes.

Detailed explanation-3: -Endothelial cells line the interior of all blood vessels. In the capillaries that form the blood–brain barrier, endothelial cells are wedged extremely close to each other, forming so-called tight junctions.

Detailed explanation-4: -Figure 2: Cellular constituents of the blood–brain barrier. The barrier is formed by capillary endothelial cells, surrounded by basal lamina and astrocytic perivascular endfeet. Astrocytes provide the cellular link to the neurons.

Detailed explanation-5: -The BBB is formed by endothelial cells (ECs), surrounded by an endothelial and astroglial basement membranes with pericytes embedded in between. These are surrounded by astrocyte endfeet that provide support to endothelial function and establish communication with neurons.