CLINICAL MEDICINE

Detailed explanation-1: -Treatment given as a first step to shrink a tumor before the main treatment, which is usually surgery, is given. Examples of neoadjuvant therapy include chemotherapy, radiation therapy, and hormone therapy.

Detailed explanation-2: -Additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back.

Detailed explanation-3: -Therefore, a better term would probably be “first-line treatment regimen or protocol.” Neoadjuvant therapy, chemotherapy given before surgery to reduce the size of a tumor, or adjuvant therapy, given after surgery to reduce the risk of recurrence, are considered components of first-line therapy in this setting.

Detailed explanation-4: -The two therapies differ largely in when they are given and why. Neoadjuvant therapies are delivered before the main treatment, to help reduce the size of a tumor or kill cancer cells that have spread. Adjuvant therapies are delivered after the primary treatment, to destroy remaining cancer cells.

Detailed explanation-5: -Select patients with early-stage breast cancer – Patients with stage I or II breast cancer are appropriate candidates for neoadjuvant therapy if breast-conserving surgery is not possible due to a high tumor-to-breast ratio, or if their anticipated cosmetic outcome would be suboptimal due to tumor location.