CLINICAL MEDICINE

Detailed explanation-1: -A study in which all the participants are given a treatment and simply followed for a period of time to see if they improve, with no comparison against another group (control group) that is either taking another treatment or no treatment at all.

Detailed explanation-2: -Uncontrolled trials belong to subset of a class of studies called nonrandomized trials, because in this trials we attempt to evaluate the effect of a intervention in a group of patients receiving that same investigational intervention.

Detailed explanation-3: -In uncontrolled or observational studies, researchers have no such control over whether their subjects receive the treatment being investigated. Uncontrolled studies thus are subject to worries about confounding variables.

Detailed explanation-4: -An experiment or clinical trial that includes a comparison (control) group.

Detailed explanation-5: -Controlled components are easier to test as their state is exposed and can be manipulated directly. Uncontrolled components, on the other hand, have internal state that is not exposed, making them harder to test.