CLINICAL MEDICINE

Detailed explanation-1: -The KRAS gene plays a role in making a protein called K-Ras, which helps cells grow and divide. You’re more likely to have a KRAS mutation if you have the adenocarcinoma type of NSCLC. A mutation on this gene also affects how your cells grow and spread.

Detailed explanation-2: -KRAS mutations occur in 20–40% of lung adenocarcinomas, a prevalence that is higher in Western vs Asian populations (26% vs. 11%) and smokers vs non-smokers (30% vs. 10%) [11]. The most frequent mutations occur in codons 12 and 13, with the most common subtypes including G12C, G12 V, and G12D (Fig.

Detailed explanation-3: -The most commonly mutated gene in people with cancer is p53 or TP53. More than 50% of cancers involve a missing or damaged p53 gene. Most p53 gene mutations are acquired. Germline p53 mutations are rare, but patients who carry them are at a higher risk of developing many different types of cancer.

Detailed explanation-4: -What is the KRAS mutation? The KRAS mutation is an error in a protein in normal cells. It is called KRAS because it was first identified as causing cancer in Kirsten RAt Sarcoma virus. Normally KRAS serves as an information hub for signals in the cell that lead to cell growth.

Detailed explanation-5: -KRAS. KRAS is the most common driver mutation found in patients with lung adenocarcinoma and occurs in both smokers and never-smokers. BRAF. BRAF mutations are found in 5% of patients with nonsquamous NSCLC. ROS1. MET. RET. HER2. Other Driver Mutations (NTRK, NRG1, Others) Brain Metastasis. 18-May-2020