CLINICAL MEDICINE

Detailed explanation-1: -A common type of epigenetic modification is called DNA methylation.

Detailed explanation-2: -Epigenetics allows the muscle cell to turn “on” genes to make proteins important for its job and turn “off” genes important for a nerve cell’s job. Your epigenetics change throughout your life. Your epigenetics at birth is not the same as your epigenetics during childhood or adulthood.

Detailed explanation-3: -Histone modifications also play an important role in epigenetic regulation. Histones are highly basic proteins that act as spools around which DNA winds in chromatin. This compacting allows the DNA to fit into a much smaller space than it would otherwise.

Detailed explanation-4: -Histone methylation is part of the most common epigenetic regulations that play important roles in developmental processes and diseases. The methylation status of lysine residues in histone proteins determines the active and silent states of surrounding genes by modulating the chromatin architecture.