MEDICINE
RADIOLOGY
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
Relatively small sample in radiogenomics research
|
|
|
Differences in facilities and protocols between institutions cause study bias
|
|
|
There is no equipment to perform whole genome sequencing that ensures accuracy in examining samples
|
|
|
There are many confounding factors in performing radiogenomics sequencing
|
Detailed explanation-1: -The first challenge in sequencing a patient’s genome is accurate base-calling, which is the identification of bases from high-intensity data generated by the optical sensors of the platforms.
Detailed explanation-2: -The short gun library, whole genome short gun sequencing, and directed gene sequencing are genome sequencing strategies. But, the Edman Degradation method is not a genome sequencing strategy.
Detailed explanation-3: -Sequence assembly is difficult because the differences between reads due to polymorphism may be misinterpreted by assemblers and errors introduced in the sequence. The alternative computer algorithms used for assembly have variable strengths and the choice of the best approach is likely to vary by organism [9].
Detailed explanation-4: -We identify three major ethical considerations that have been implicated in whole-genome research: the return of research results to participants; the obligations, if any, that are owed to participants’ relatives; and the future use of samples and data taken for whole-genome sequencing.