EVERYDAY SCIENCE

Detailed explanation-1: -The nucleus from a cancer cell is larger and darker because it often contains too much DNA.

Detailed explanation-2: -"In general, cancer cells have larger nuclei than normal cells, ” says Fernando U. Garcia, MD, Pathologist at our hospital in Philadelphia. “This is mainly due to alterations in the DNA that have resulted in the development of cancer.

Detailed explanation-3: -Normal cells have normal DNA and a normal number of chromosomes. Cancer cells often have an abnormal number of chromosomes and the DNA becomes increasingly abnormal as it develops a multitude of mutations. Some of these are driver mutations, meaning they drive the transformation of the cell to be cancerous.

Detailed explanation-4: -[208] reported that in many cancer cells, the nuclear envelope transiently ruptures and then reseals during interphase, resulting in temporary exchange between the nucleus and cytoplasm and the occasional entrapment of cytoplasmic organelles inside the nucleus.

Detailed explanation-5: -The inner diameter of many cancer cell lines is greater than 10 µm, in contrast to normal cells. For the detection of WBC having similar size to that of cancer cells, we developed a PC software “Cancer Cell Finder” that differentiates them from cancer cells based on brightness stationary points on a cell surface.