LIFE SCIENCE

Detailed explanation-1: -When an enzyme is denatured, it loses it native conformation, or three-dimensional structure. A denatured enzyme is unable to bind to its substrate and increase the chemical rate of reaction.

Detailed explanation-2: -When the shape of an enzyme (and more specifically its active site) changes, it is no longer able to bind to its substrate. The enzyme is deactivated and no longer has an effect on the rate of the reaction. Enzymes can also be deactivated by other molecules.

Detailed explanation-3: -Enzymes work consistently until they are dissolved, or become denatured. When enzymes denature, they are no longer active and cannot function. Extreme temperature and the wrong levels of pH–a measure of a substance’s acidity or alkalinity–can cause enzymes to become denatured.

Detailed explanation-4: -Enzyme structures unfold (denature) when heated or exposed to chemical denaturants and this disruption to the structure typically causes a loss of activity. Protein folding is key to whether a globular protein or a membrane protein can do its job correctly. It must be folded into the right shape to function.