LIFE SCIENCE

Detailed explanation-1: -An irreversible inhibitor inactivates an enzyme by bonding covalently to a particular group at the active site.

Detailed explanation-2: -Explanation: Competitive inhibitors bind to the active site of the enzyme and prevent substrates from binding to enzyme. This prevents the enzyme-substrate reaction from happening, thereby decreasing the activity of enzymes; however, competitive inhibitors can be overcome by increasing the concentration of substrates.

Detailed explanation-3: -The competitive inhibitor binds to the active site and prevents the substrate from binding there. The noncompetitive inhibitor binds to a different site on the enzyme; it doesn’t block substrate binding, but it causes other changes in the enzyme so that it can no longer catalyze the reaction efficiently.

Detailed explanation-4: -In noncompetitive inhibition, the inhibitor binds at an allosteric site separate from the active site of substrate binding. Thus in noncompetitive inhibition, the inhibitor can bind its target enzyme regardless of the presence of a bound substrate.

Detailed explanation-5: -Uncompetitive inhibition occurs when the inhibitor binds to the enzyme–substrate complex and prevents the reaction from being catalyzed.