OBJECTIVE LIFE SCIENCE
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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charge
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stress
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speed
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alignment
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Detailed explanation-1: -The change of pH will lead to the ionization of amino acids atoms and molecules, change the shape and structure of proteins, thus damaging the function of proteins. Enzymes are also proteins, which are also affected by changes in pH.
Detailed explanation-2: -Changing the pH disrupts the hydrogen bonds, and this changes the shape of the protein.
Detailed explanation-3: -The total charge on the proteins standardly decreases from positive to negative as the pH increases, crossing the point of zero charge at the isoelectric point, pI.
Detailed explanation-4: -The role of the concentration of hydrogen ions on protein stability is demonstrated by acidic/basic unfolding 5–8 and protein pH-dependent stability 9–14. Changes in pH are shown to trigger formation of amyloid fibers and aggregation 15–19.