LIFE SCIENCE

Detailed explanation-1: -The spliceosome is a large, protein-RNA complex that consists of five small nuclear RNAs (U1, U2, U4, U5, and U6) and over 150 proteins. The snRNAs, along with their associated proteins, form ribonucleoprotein complexes (snRNPs), which bind to specific sequences on the pre-mRNA substrate.

Detailed explanation-2: -A wide range of biochemical and genetical studies shows that the spliceosome comprises three major RNA-protein subunits, the U1, U2 and [U4/U6. U5] small nuclear ribonucleoprotein particles (snRNPs), and an additional group of non-snRNP protein splicing factors.

Detailed explanation-3: -Each spliceosome is composed of five small nuclear RNAs (snRNA) and a range of associated protein factors.

Detailed explanation-4: -snRNAs participate in the pre-mRNA splicing reaction as a small nuclear ribonucleoprotein (snRNP) complex, which includes a single spliceosomal snRNA in complex with a number of proteins. Spliceosomal snRNPs are key components of the spliceosome and are absolutely required for pre-mRNA splicing.