OBJECTIVE LIFE SCIENCE
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which enzyme is responsible for proofreading the newly composed DNA strand?
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DNA Polymerase
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Topoisomerase
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Ligase
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Primase
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Explanation:
Detailed explanation-1: -The other major mechanism responsible for the accuracy of DNA replication is the proofreading activity of DNA polymerase. As already noted, E. coli polymerase I has 3′ to 5′ as well as 5′ to 3′ exonuclease activity.
Detailed explanation-2: -A 3´→ 5´ proofreading exonuclease domain is intrinsic to most DNA polymerases. It allows the enzyme to check each nucleotide during DNA synthesis and excise mismatched nucleotides in the 3´ to 5´ direction.
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