OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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A proteoglycan which serves to assemble a complex containing granzymes and perforin is known as?
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Serglycin
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Cytokine
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Cytotoxic T-Cell
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Cytotoxic B-Cell
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Explanation:
Detailed explanation-1: -CTL and NK cell granules contain perforin and granzymes The lytic granules contain the pore-forming protein perforin and a series of granule-associated enzymes, called granzymes.
Detailed explanation-2: -Pancreatic cells may be destroyed in perforin/granzyme B-dependent pathway, Fas/FasL-dependent pathway as well as in a consequence of proinflammatory cytokines release (interferon, interleukins). It was shown that more than one cytotoxic mechanism is involved in cells destruction.
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