OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Secondary mediators (leukotrienes and prostaglandins produced by innate immune cells) are 1000x more potent than histamine at inducing bronchoconstriction and more potent stimulators of:
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vascular permeability
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mucous secretion
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asthma
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vascular constriction
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neuropathy
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Explanation:
Detailed explanation-1: -Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process.
Detailed explanation-2: -LTB4 is the most important leukotriene in acute inflammatory responses; it activates leukocytes and prolongs their survival. Additionally, LTB4 is a powerful chemoattractant for neutrophils and macrophages and stimulates leukocyte adhesion to vascular endothelium by upregulating integrin expression.
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