LIFE SCIENCE

Detailed explanation-1: -It controls the production of the proteases (enzymes) that break down the corneodesmosomes – the strong bonds between the cells in the stratum corneum.

Detailed explanation-2: -Causes of filaggrin deficiency Skin inflammation (e.g., from atopic dermatitis or psoriasis), which can cause a decrease in the natural production of filaggrin and the enzyme that breaks down filaggrin into water-binding amino acids.

Detailed explanation-3: -Eczema is caused by problems with the skin barrier. Many children with eczema do not have enough of a special protein called “filaggrin” in the outer layer of skin. Filaggrin helps skin form a strong barrier between the body and the environment.