Mast cells express two types of receptors:FcεRI (activating) and FcγRIIB (inhibiting) Ig receptors. If a cell binds both IgE and IgG, which signal wins? (Hint:this is what makes allergy shots effective)

SIGNALLING IMMUNOLOGY CANCER

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

Mast cells express two types of receptors:FcRI (activating) and FcRIIB (inhibiting) Ig receptors. If a cell binds both IgE and IgG, which signal wins? (Hint:this is what makes allergy shots effective)

A	IgE
B	IgG
C	Either A or B
D	None of the above

Explanation:

Detailed explanation-1: -Fc Receptors. There are two IgE receptors: FcRI is the high-affinity IgE receptor that is expressed by mast cells and basophils and by dendritic cells and Langerhans cells in the skin.

Detailed explanation-2: -Histamine is not only released when the body encounters a toxic substance, it is also released when mast cells detect injury. It causes nearby blood vessels to dilate allowing more blood to reach the site of the injury or infection.

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SIGNALLING IMMUNOLOGY CANCER