OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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These molecules are responsible for inducing a fever during the innate immune response.
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interferons
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cytokines
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complement
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antibodies
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Explanation:
Detailed explanation-1: -These innate immune cells release prostaglandin E2 (PGE2) as well as pyrogenic cytokines (namely, interleukin-1 (IL-1) IL-6, and tumour necrosis factor (TNF)) that act systemically to induce fever.
Detailed explanation-2: -These cytokines stimulate the anterior hypothalamus of the brain, the part of the brain that regulates body temperature, to produce prostaglandin E2, which leads to an increase bodily heat production and increased vasoconstriction.
Detailed explanation-3: -Fever is part of a systemic response to infection known as the acute phase response (Box 1). Fever itself is the controlled elevation of body temperature due to the upward resetting of the hypothalamic thermostat.
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