OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What is a class of bacterial toxins and viral proteins that can non-specifically bind the MHC-II molecule of an APC with the TCR of a T-cell in a tight adhesion of the two cells, thus leading to massive T-cell activation and the release of large amounts of cytokines?
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Superantigen
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Supertoxin
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Superantibody
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Superbug
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Explanation:
Detailed explanation-1: -Superantigens are unusual bacterial toxins that interact with exceedingly large numbers of T4-lymphocytes. They bind to the surface of the target cell but do not enter the cell. Figure 16.6. 1: Binding of Peptide Epitopes from Exogenous Antigens to MHC-II Molecules.
Detailed explanation-2: -Superantigens have been associated with many illnesses caused by S. aureus infections. One of the most well-recognized diseases is Toxic Shock Syndrome (TSS), a potentially lethal febrile illness related to multiorgan dysfunction that occurs as a consequence of the cytokine storm produced by SAgs.
Detailed explanation-3: -6.2A: Type I Toxins: Superantigens.
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