OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
Ig M, Ig G
|
|
|
Ig A, Ig E
|
|
|
Ig G, Ig E
|
|
|
Ig M, Ig A
|
Detailed explanation-1: -IgE is not believed to play an important role in defense against bacterial infections, since it does not activate complement or participate in opsonization [5]. IgE plays a key role in the pathogenesis of allergic diseases, especially mast cell/basophil activation, and in antigen presentation.
Detailed explanation-2: -A human monoclonal IgE from patient DES, IgE (DES), has been shown to activate the classical pathway of complement. The mechanism of this activation has been investigated and can be summarized as follows: (a) IgE (DES) is able to bind and activate C1 in a dose-dependent fashion.
Detailed explanation-3: -Human IgA activates the complement system via the mannan-binding lectin pathway. J Immunol.
Detailed explanation-4: -It is well known that both IgG and IgM can activate complement via the classical pathway by binding of C1q to the Fc regions of these immunoglobulins. Recent advances have shown that also IgA is capable of activating the complement system.