OBJECTIVE LIFE SCIENCE
SIGNALLING IMMUNOLOGY CANCER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which of the following areas on an antibody would be responsible for causing an M1 macrophage to do phagocytosis?
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Variable region-light chain
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Variable region-heavy chain
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Hinge region
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Constant region
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Explanation:
Detailed explanation-1: -One of the most important functions performed by macrophages during the induction of an immune response may be the presentation of antigen to antibody-forming cell precursors in a molecular form appropriate for cell activation.
Detailed explanation-2: -M1 macrophages are characterized by an elevated ability to secrete cytokines such as IL-1, TNF, IL-12, and IL-18; phenotypically, they express high levels of main histocompatibility complex class II (MHC-II), CD68 marker, and CD80 and CD86 costimulatory molecules.
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