PHYSIOLOGY
ENDOCRINOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Glucose Suppression Test
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Arginine Stimulation Test
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Insulin Tolerance Test
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Serum IGF 1 levels
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Detailed explanation-1: -This is the best method for confirming an acromegaly diagnosis. During this test, your GH blood level is measured both before and after you drink a preparation of sugar (glucose). In people who don’t have acromegaly, the glucose drink typically causes the GH level to fall.
Detailed explanation-2: -An oral glucose suppression test is done to find out if the pituitary gland is releasing too much growth hormone (GH). The pituitary gland is a small gland (about the size of a pea) in the brain. It releases hormones into the bloodstream that affect growth.
Detailed explanation-3: -An OGTT with 75 g glucose is considered the gold standard for diagnosing acromegaly.
Detailed explanation-4: -Measurement of GH after oral glucose tolerance test (OGTT) is used for the diagnosis and surveillance of acromegaly. However, there are major discrepancies between glucose-suppressed GH and plasma IGF1 as indices of biochemical activity of acromegaly in patients with relatively mild GH oversecretion.