MEDICAL PHYSIOLOGY

Detailed explanation-1: -Tropomyosin covers the actin binding sites, preventing myosin from forming cross-bridges while in a resting state. When calcium binds to troponin, the troponin changes shape, removing tropomyosin from the binding sites.

Detailed explanation-2: -Contraction of Skeletal Muscle Therefore, it is believed that the active sites on the normal actin filament of the relaxed muscle are inhibited or physically covered by the troponin-tropomyosin complex. Consequently, the sites cannot attach to the heads of the myosin filaments to cause contraction.

Detailed explanation-3: -Contraction of Skeletal Muscle Therefore, it is believed that the active sites on the normal actin filament of the relaxed muscle are inhibited or physically covered by the troponin-tropomyosin complex. Consequently, the sites cannot attach to the heads of the myosin filaments to cause contraction.

Detailed explanation-4: -Tropomyosin regulates actin filament functions in most eukaryotic muscle and non-muscle cells in organisms ranging from mammals to fungi.