MEDICAL PHYSIOLOGY

Detailed explanation-1: -The neurotransmitters implicated in migraine pathogenesis include: serotonin, dopamine and glutamate. An alteration in the balance of any of these neurological systems may lead to a higher susceptibility to migraine.

Detailed explanation-2: -Migraine involves alteration in the excitability of multiple regions of the central nervous system (CNS). Glutamate is the most important and widely distributed excitatory neurotransmitter in the CNS, and therefore likely plays a crucial role in migraine pathophysiology [1].

Detailed explanation-3: -Glutamate is an excitatory neurotransmitter with several types of receptors found throughout the central nervous system, and its metabolism is important to maintaining optimal levels within the extracellular space. As such, it is important to memory, cognition, and mood regulation.

Detailed explanation-4: -There are a number of neurotransmitters used by the body for different functions, including acetylcholine, glutamate, GABA, glycine, dopamine, norepinephrine, and serotonin. Glutamate is the principal excitatory neurotransmitter used in the brain.