MEDICAL PHYSIOLOGY

Detailed explanation-1: -Uric acid is generated from metabolic conversion of either exogenous (dietary) or endogenous purines, primarily in the liver and intestine. The immediate precursor of uric acid is xanthine, which is metabolized to uric acid by either xanthine oxidase or by its isoform, xanthine dehydrogenase.

Detailed explanation-2: -Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the end product of an exogenous pool of purines, and endogenously from damaged, dying and dead cells, whereby nucleic acids, adenine and guanine, are degraded into uric acid.

Detailed explanation-3: -In humans the final compound of purines catabolism is uric acid. All other mammals possess the enzyme uricase that converts uric acid to allantoin that is easily eliminated through urine. Overproduction of uric acid, generated from the metabolism of purines, has been proven to play emerging roles in human disease.

Detailed explanation-4: -Purine disintegrates into uric acid. Increased uric acid levels from excess purines might collect and form crystals in your tissues. It can produce excessive amounts of uric acid in the blood. The production of uric acid may occur if blood uric acid levels are higher than 7 mg/dL.