MEDICAL PHYSIOLOGY

Detailed explanation-1: -Acetylcholinesterase (AChE) is a cholinergic enzyme primarily found at postsynaptic neuromuscular junctions, especially in muscles and nerves. It immediately breaks down or hydrolyzes acetylcholine (ACh), a naturally occurring neurotransmitter, into acetic acid and choline.

Detailed explanation-2: -If acetylcholinesterase breaks down acetylcholine, then acetylcholinesterase function must be to eliminate the signal that acetylcholine produces. Acetylcholinesterase prevents: Overstimulation of muscle fibers. Muscle fatigue.

Detailed explanation-3: -Free acetylcholine within the synaptic cleft is degraded by an enzyme called acetylcholinesterase. This enzyme assures that no excess of acetylcholine remains in the synaptic cleft to cause the continuous activation of receptors.

Detailed explanation-4: -Acetylcholine is a small molecule that acts as a chemical messenger to propagate nerve impulses across the neuromuscular junction between a nerve and a muscle. When the nerve impulse from a motor neuron arrives at the tip of its axon, acetylcholine molecules stored there in vesicles are released into the synaptic gap.

Detailed explanation-5: -At the neuromuscular junction, the nerve fiber is able to transmit a signal to the muscle fiber by releasing ACh (and other substances), causing muscle contraction.