MEDICAL PHYSIOLOGY

Detailed explanation-1: -In physiology, the all-or-none law (sometimes the all-or-none principle or all-or-nothing law) is the principle that if a single nerve fibre is stimulated, it will always give a maximal response and produce an electrical impulse of a single amplitude.

Detailed explanation-2: -The all or none principle means that signal transmission between neurons is not dependent on the strength of the stimuli but, rather, only that the initial threshold is met. In other words, neurons will either transmit an impulse over the synapse to the next neuron completely or not at all.

Detailed explanation-3: -Discovery of the All-or-None Law While the all-or-none law was initially applied to the muscles of the heart, it was later found that neurons and other muscles also respond to stimuli according to this principle.

Detailed explanation-4: -The all-or-none law is the principle that the strength by which a nerve or muscle fiber responds to a stimulus is independent of the strength of the stimulus. If that stimulus exceeds the threshold potential, the nerve or muscle fiber will give a complete response; otherwise, there is no response.

Detailed explanation-5: -all-or-none law, a physiological principle that relates response to stimulus in excitable tissues. It was first established for the contraction of heart muscle by the American physiologist Henry P. Bowditch in 1871.