MEDICAL PHYSIOLOGY

Detailed explanation-1: -With the stimulation of the presynaptic terminal, acetylcholine is released from the vesicles and into the synaptic cleft, where the neurotransmitter is free to bind with receptors.

Detailed explanation-2: -As a result of the action potential, the chemical transmitter acetylcholine (ACh) is released into the synaptic cleft. ACh diffuses across the synaptic cleft and binds to special receptors on the postsynaptic or the postjunctional membrane.

Detailed explanation-3: -The [Ca2+] binds to proteins that dock synaptic vesicles at the active zone, leading to fusion of the vesicles with the presynaptic membrane and release of neurotransmitter, acetylcholine, into the synapse.

Detailed explanation-4: -Acetylcholine is actively transported from the presynaptic membrane to the postsynaptic membrane.

Detailed explanation-5: -Communication at chemical synapses requires release of neurotransmitters. When the presynaptic membrane is depolarized, voltage-gated Ca2+ channels open and allow Ca2+ to enter the cell. The calcium entry causes synaptic vesicles to fuse with the membrane and release neurotransmitter molecules into the synaptic cleft.