MEDICAL PHYSIOLOGY

Detailed explanation-1: -The sequence of events that forms the link between electrical activity in the sarcolemma and the initiation of a contraction is called excitation-contraction coupling.

Detailed explanation-2: -As ACh binds at the motor end plate, this depolarization is called an end-plate potential. The depolarization then spreads along the sarcolemma, creating an action potential as sodium channels adjacent to the initial depolarization site sense the change in voltage and open.

Detailed explanation-3: -The process of conversion of the action potential on the motor neuron to an action potential on the muscle fiber is called neuromuscular transmission. The action potential on the muscle fiber then activates the muscle by a process called excitation–contraction coupling.

Detailed explanation-4: -Electrical Stimulation Depolarization of the sarcolemma leads to opening of voltage-gated Ca2+ channels and influx of Ca2+ from the extracellular space. This Ca2+ pulse can also trigger the release of intracellular Ca2+ from the sarcoplasmic reticulum (Ca2+-induced Ca2+ release, CICR).