MEDICAL PHYSIOLOGY

Detailed explanation-1: -The thick filaments are composed of myosin with the globular heads forming cross-bridges with thin filaments . Myosin-binding proteins, including MyBP-C, are associated with the thick filaments. The giant protein titin extend the length of an entire half sarcomere.

Detailed explanation-2: -The thick filaments of muscle consist of several hundred myosin molecules, associated in a parallel staggered array by interactions between their tails (Figure 11.23). The globular heads of myosin bind actin, forming cross-bridges between the thick and thin filaments.

Detailed explanation-3: -The thick filament is made up of bipolar, elongated proteins called myosin. There are about 300-500 myosin molecules in a sarcomere and they are located at the center of the sarcomere. A myosin molecule looks like two golf clubs intertwined, with the heads pointing out from the surface of the thick filament.