NEET BIOLOGY

Detailed explanation-1: -Streptokinase is an enzyme produced by many strains of -haemolytic streptococci isolated naturally from upper respiratory tract and is used to dissolve the fibrin matrix of blood clots, especially those in the arteries of the heart and lungs.

Detailed explanation-2: -Streptokinase is an extracellular protein, extracted from certain strains of beta hemolytic streptococcus.

Detailed explanation-3: -Introduction. Streptokinase (SK) is a bacterial plasminogen (Pgn) binding and activating protein widely used as a therapeutic thrombolytic agent [1].

Detailed explanation-4: -Many pathogenic streptococci secrete streptokinase in order to accelerate the conversion of human plasminogen to plasmin (12). Lacking enzymatic activity itself, streptokinase evolves its function by forming a stoichiometric 1:1 complex with plasminogen or a trimolecular complex with plasminogen and fibrinogen.

Detailed explanation-5: -Streptokinase is a novel bacterial enzyme that binds with plasminogen and activates it. Streptokinase is produced by different species of streptococcus. Activity of streptokinase is determined by different methods such as fibrin clot method, casein hydrolysis and Chromozym test.