GENETICS AND EVOLUTION
MOLECULAR BASIS OF INHERITANCE
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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On the lagging strand in replication, the Okazaki fragments must be joined by which enzyme?
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DNA polymerase
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primase
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ligase
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helicase
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Explanation:
Detailed explanation-1: -During lagging strand synthesis, DNA ligase I connects the Okazaki fragments, following replacement of the RNA primers with DNA nucleotides by DNA polymerase .
Detailed explanation-2: -The last deoxyribonucleotide is joined by a different enzyme, DNA ligase, which uses one ATP to join the Okazaki fragment into the growing lagging strand.
Detailed explanation-3: -Okazaki segments are joined by DNA ligase.
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