Pharmacogenetics is an increasingly important discipline that uses genetic information to tailor the prescription of drug treatments to individuals. In the case of chemotherapy for breast cancer, for example, different patients need and/or respond to different treatments.Patients whose tumors are HER-2 positive respond to herceptin whereas other patients do not. Patients whose tumors have estrogen receptors will be best served if .....

MOLECULAR BASIS OF INHERITANCE

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

Pharmacogenetics is an increasingly important discipline that uses genetic information to tailor the prescription of drug treatments to individuals. In the case of chemotherapy for breast cancer, for example, different patients need and/or respond to different treatments.Patients whose tumors are HER-2 positive respond to herceptin whereas other patients do not. Patients whose tumors have estrogen receptors will be best served if ____

A	the estrogen receptors are blocked by other molecules that can use the same receptors.
B	their estrogen release is activated and/or elevated.
C	they are given herceptin as well as estrogen.
D	their estrogen receptors are blocked by using RNAi.

Explanation:

Detailed explanation-1: -Example: Depression and Amitriptyline. The breakdown of the antidepressant drug amitriptyline is influenced by two genes called CYP2D6 and CYP2C19. If your doctor prescribes amitriptyline, he or she might recommend genetic testing for the CYP2D6 and CYP2C19 genes to help decide what dose of the drug you need.

Detailed explanation-2: -The pharmacogenomics approach enables identifying all the genetic variations in driver genes that account for the selective growth of cells in tumor bulk. As therapeutic targets, these help the clinician to select the appropriate therapeutic regimens to overcome resistance.

Detailed explanation-3: -Pharmacogenetics is the study of genetic causes of individual variations in drug response whereas pharmacogenomics deals with the simultaneous impact of multiple mutations in the genome that may determine the patient’s response to drug therapy.

Detailed explanation-4: -Pharmacogenetics aims to identify individuals predisposed to high risk of toxicity from conventional doses of cancer chemotherapeutic agents. We review the role of genetic polymorphisms in UGT1A1 and TPMT, as well as mutations in DPD, in influencing drug disposition and toxicity.

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NEET BIOLOGY

GENETICS AND EVOLUTION

MOLECULAR BASIS OF INHERITANCE