GENETICS AND EVOLUTION
MOLECULAR BASIS OF INHERITANCE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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It catalyzes the lengthening of telomeres.
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It synthesizes RNA nucleotides to make a primer.
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It unwinds the parental double helix.
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It joins Okazaki fragments together.
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Detailed explanation-1: -The latter strand comprises of several fragments known as the Okazaki fragment which needs to be sealed. These Okazaki fragments are sealed with the help of DNA ligase enzyme which ensures the formation of the chemical bond accompanied by hydrolysis.
Detailed explanation-2: -One of the enzymes involved in DNA replication is the DNA ligase. This is a specific enzyme that connects the gap or nick between two nucleotides by attaching it by the formation of a phosphodiester bond. This process requires ATP for it to occur. The phosphate backbone in the DNA molecule is sealed by the DNA ligase.
Detailed explanation-3: -DNA ligases play an essential role in maintaining genomic integrity by joining breaks in the phosphodiester backbone of DNA that occur during replication and recombination, and as a consequence of DNA damage and its repair.
Detailed explanation-4: -DNA ligases are best known for their role in joining adjacent Okazaki fragments at the lagging strand of the replication fork; however, they are essentially involved in any process that requires sealing of phosphodiester bonds from the DNA backbone.
Detailed explanation-5: -Explanation: DNA ligase is the protein responsible for linking, or ligating, Okazaki fragments together in order to form a single complete DNA strand.