HUMAN PHYSIOLOGY
DIGESTION AND ABSORPTION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Trypsin
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Pepsin
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Chymotrypsin
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Carboxypeptidase
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Aminopeptidase
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Detailed explanation-1: -121 Carboxypeptidase A is normally synthesized as a zymogen that is inactive without proteolytic removal of its propeptide end by trypsin.
Detailed explanation-2: -Although pancreatic CPB is responsible for the intestinal digestion of food proteins and peptides, the other basic carboxypeptidases are not digestive enzymes but have regulatory effects on the activity of biological peptides such as anaphylatoxins, enkephalins and bradykinins [1].
Detailed explanation-3: -Carboxypeptidase A (CPA) contains a zinc (Zn2+) metal center in a tetrahedral geometry with amino acid residues in close proximity around zinc to facilitate catalysis and binding.
Detailed explanation-4: -Carboxypeptidase M (EC 3.4. 17.12) belongs to the family of the carboxypeptidases. These enzymes remove C-terminal amino acids from peptides and proteins and exert roles in the physiological processes of blood coagulation/fibrinolysis, inflammation, food digestion and pro-hormone and neuropeptide processing.