NEET PG DENTAL EXAM

Detailed explanation-1: -GABA is the main neurotransmitter used in the basal ganglia network, and abnormal transmission at specific GABAergic synapses underlies some of the pathophysiological features of various basal ganglia diseases.

Detailed explanation-2: -Although glutamate is the most common neurotransmitter here as everywhere in the brain, the inhibitory neurotransmitter GABA plays the most important role in the basal ganglia.

Detailed explanation-3: -gamma-Aminobutyric acid type A (GABA(A)) receptors, the major inhibitory neurotransmitter receptors responsible for fast inhibition in the basal ganglia, belong to the superfamily of “cys-cys loop” ligand-gated ion channels.

Detailed explanation-4: -This pathway projects from the substantia nigra pars compacta to the striatum, and it utilizes the neurotransmitter dopamine. This pathway has a modulatory effect on the basal ganglia, with dopamine facilitating the motor loop in these two ways: It excites the direct pathway.