SSC
BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Protein ____ are enzymes that activate or deactivate other proteins by phosphorylating them. To be active, each ____ must be attached to a ____, a protein that gets its name from its cyclically fluctuating concentration in the cell
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cyclin, kinases, enzyme
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enzymes, kinases, cyclin
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kinases, kinases, cyclin
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None of the above
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Explanation:
Detailed explanation-1: -Two groups of proteins, called cyclins and cyclin-dependent kinases (Cdks), are responsible for the progress of the cell through the various checkpoints.
Detailed explanation-2: -The formation of cyclin/CDKs controls the cell-cycle progression via phosphorylation of the target genes, such as tumor suppressor protein retinoblastoma (Rb). The activation of cyclins/CDKs is induced by mitogenic signals and inhibited by the activation of cell-cycle checkpoints in response to DNA damage [8].
Detailed explanation-3: -Formation of the cyclin/CDK complexes results in phosphorylation and activation of the CDKs. Activated cyclin/CDK complexes phosphorylate specific protein substrates that enable cell cycle progression.
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