WORLD HISTORY

Detailed explanation-1: -"Without vaccines and appropriate drugs, we would probably be overwhelmed by viruses and bacteria, ‘’ Angetter says. The fact that our immune system can now deal with most viruses relatively well is also due to vaccinations, according to the OeAW researcher.

Detailed explanation-2: -Immunosuppression due to a variety of factors including stress, malnutrition, concurrent infection, or immaturity or senescence of the immune system may also lead to vaccination failure. If the immunosuppression occurs at the time of vaccination, the vaccine may fail to induce an adequate immune response.

Detailed explanation-3: -Spanish physician Jamie Ferrán developed a vaccine against cholera in 1885. The same year, the animal vaccine against rabies was successfully used in humans. English physician S. Monkton Copeman demonstrated that glycerin acted as a germicide when added to vaccines in 1891.

Detailed explanation-4: -Live, attenuated vaccines can cause severe or fatal reactions in immunosuppressed persons due to uncontrolled replication of the vaccine virus. Live vaccines should usually not be administered to severely immunosuppressed persons with congenital immunodeficiency, leukemia, lymphoma, or generalized malignancy.

Detailed explanation-5: -Vaccines have led to the eradication of life-threatening or life-debilitating diseases. Smallpox, for example, was one of the most contagious and deadly diseases, claiming the life of 300 million people between the years of 1900-1920. It has since been eradicated because of a vaccine.