WORLD HISTORY

Detailed explanation-1: -In Russia, Tsarevich Alexei, the son and heir of Tsar Nicholas II, famously had haemophilia, which he had inherited from his mother, Empress Alexandra, one of Queen Victoria’s granddaughters. The haemophilia of Alexei would result in the rise to prominence of the Russian mystic Grigori Rasputin, at the imperial court.

Detailed explanation-2: -So, it was an absolute state secret that Aleksei had the condition. And Nicholas and Alexandra managed to keep it secret until 1912 when Aleksei had a profoundly serious attack of bleeding and almost died. How did the Romanov family treat Aleksei’s hemophilia? In 1904, hemophilia was little understood.

Detailed explanation-3: -Hemophilia is caused by a mutation or change, in one of the genes, that provides instructions for making the clotting factor proteins needed to form a blood clot. This change or mutation can prevent the clotting protein from working properly or to be missing altogether. These genes are located on the X chromosome.

Detailed explanation-4: -Hemophilia is a rare disorder in which the blood doesn’t clot in the typical way because it doesn’t have enough blood-clotting proteins (clotting factors). If you have hemophilia, you might bleed for a longer time after an injury than you would if your blood clotted properly.

Detailed explanation-5: -Hemophilia is sometimes referred to as “the royal disease, ‘’ because it affected the royal families of England, Germany, Russia and Spain in the 19th and 20th centuries. Queen Victoria of England, who ruled from 1837-1901, is believed to have been the carrier of hemophilia B, or factor IX deficiency.

Detailed explanation-6: -The major types of this condition are hemophilia A (also known as classic hemophilia or factor VIII deficiency) and hemophilia B (also known as Christmas disease or factor IX deficiency).