BIOMOLECULES AND ENZYMES

Detailed explanation-1: -Negatively charged R group : Aspartic acid and glutamic acid. So both glutamic acid and aspartic acid are acidic amino acids.

Detailed explanation-2: -Acidic Amino Acids (Dicarboxylic) Aspartic acid and glutamic acid are amino acids that have an additional carboxyl group that can release a proton and acquire a negative charge at the pH of body fluids. Often, these amino acids are designated with the name of their ionized form, aspartate and glutamate, respectively.

Detailed explanation-3: -Glutamic Acid E (Glu) The pKa of the carboxyl group for glutamic acid in a polypeptide is about 4.3, significantly higher than that of aspartic acid. This is due to the inductive effect of the additional methylene group.

Detailed explanation-4: -Aspartic acid, like glutamic acid, is classified as an acidic amino acid, with a pKa of 3.9, however in a peptide this is highly dependent on the local environment, and could be as high as 14. Asp is pervasive in biosynthesis. A molecular entity capable of donating a hydron to an acceptor (Br o nsted base).

Detailed explanation-5: -Two amino acids have acidic side chains at neutral pH. These are aspartic acid or aspartate (Asp) and glutamic acid or glutamate (Glu). Their side chains have carboxylic acid groups.