BIOMOLECULES AND ENZYMES

Detailed explanation-1: -However, extreme high temperatures can cause an enzyme to lose its shape (denature) and stop working. pH: Each enzyme has an optimum pH range. Changing the pH outside of this range will slow enzyme activity. Extreme pH values can cause enzymes to denature.

Detailed explanation-2: -Changing the pH will affect the charges on the amino acid molecules. Amino acids that attracted each other may no longer be. Again, the shape of the enzyme, along with its active site, will change. Extremes of pH also denature enzymes.

Detailed explanation-3: -As an enzyme is heated beyond its optimum temperature, the hydrogen bonds holding the protein together vibrate and, with increasing temperature, will break. When an enzyme is in a non-optimum pH, the differing proportion of hydrogen ions (which cause changing pH)) will affect those bonds which contain a charge.

Detailed explanation-4: -What denatures enzymes? There are two main causes for enzyme denaturation: temperature and pH. Enzymes function best at the optimal temperature of an organism.

Detailed explanation-5: -Therefore, any change to the shape of the enzyme is going to have a huge impact on its function. If the enzyme is denatured, it will not be able to selectively bind substrates, leading to a loss of function.