BIOMOLECULES AND ENZYMES

Detailed explanation-1: -Instead, an enzyme changes shape slightly when it binds its substrate, resulting in an even tighter fit. This adjustment of the enzyme to snugly fit the substrate is called induced fit. Illustration of the induced fit model of enzyme catalysis.

Detailed explanation-2: -The induced-fit model was first proposed by Koshland in 1958 to explain the protein conformational changes in the binding process. This model suggests that an enzyme, when binding with its substrate, optimizes the interface through physical interactions to form the final complex structure.

Detailed explanation-3: -The induced fit model states an substrate binds to an active site and both change shape slightly, creating an ideal fit for catalysis. When an enzyme binds its substrate it forms an enzyme-substrate complex.

Detailed explanation-4: -Induced fit indicates a continuous change in the conformation and shape of an enzyme in response to substrate binding. This makes the enzyme catalytic which results in the lowering of the activation energy barrier causing an increase in the overall rate of the reaction.