BIOMOLECULES AND ENZYMES

Detailed explanation-1: -During and after protein translation, molecular chaperones require ATP hydrolysis to favor the native folding of their substrates and, under stress, to avoid aggregation and revert misfolding.

Detailed explanation-2: -Molecular chaperones are guardians of the proteome that assist in protein folding and prevent the accumulation of aberrant protein conformations that can lead to proteotoxicity. ATP-independent chaperones do not require ATP to regulate their functional cycle.

Detailed explanation-3: -Molecular chaperones are essential to protein folding and can prevent protein aggregation by binding to non-specific proteins.

Detailed explanation-4: -Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis. Nature.