BIOLOGY
PROTEINS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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A A few amino acids give the active site a specific shape
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B An enzyme has a substrate with a specific shape.
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C The enzyme changes shape in the presence of the substrate.
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D The substrate molecules are complementary to the active site.
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Detailed explanation-1: -The active site can be influenced by molecules binding elsewhere on an enzyme, but the induced fit must occur prior to the Initial binding of enzyme and substrate. In order for the reaction t0 proceed, the binding of enzyme and substrate is weakest in the transition state.
Detailed explanation-2: -The induced-fit model was first proposed by Koshland in 1958 to explain the protein conformational changes in the binding process. This model suggests that an enzyme, when binding with its substrate, optimizes the interface through physical interactions to form the final complex structure.
Detailed explanation-3: -Expert-Verified Answer. The second statement is correct. Once the enzyme binds to the specific substrate molecule, structural changes can occur in the enzyme’s active site to accommodate the product which is the substrate in a transitional state until the reaction is complete to yield the final product.
Detailed explanation-4: -The induced-fit model states a substrate binds to an active site and both change shape slightly, creating an ideal fit for catalysis. Enzymes promote chemical reactions by bringing substrates together in an optimal orientation, thus creating an ideal chemical environment for the reaction to occur.