BIOMOLECULES AND ENZYMES

Detailed explanation-1: -Thiamine deficiency is a medical condition of low levels of thiamine (Vitamin B1). A severe and chronic form is known as beriberi. The two main types in adults are wet beriberi and dry beriberi. Wet beriberi affects the cardiovascular system, resulting in a fast heart rate, shortness of breath, and leg swelling.

Detailed explanation-2: -Increased preload and myocardial dysfunction ultimately leads to congestive heart failure. Wet beriberi mainly triggers right heart failure. The moderate pulmonary hypertension is common for wet beriberi patient. Our patient had a pulmonary hypertension of 57 mmHg.

Detailed explanation-3: -Heart rate was not affected and the EEG exhibited arousal effects after B1 treatment. It is suggested that in the failing heart with increased sympathetic tone thiamine acts as a mild peripheral vasodilator followed by a diminished pump outflow impedance and a resultant increase in systolic blood pressure.