BIOMOLECULES AND ENZYMES

Detailed explanation-1: -Dietary deficiency of niacin results in pellagra. It is characterized by dermatitis, diarrhea, dementia, and eventually death if not treated by giving niacin. This is why it is called the 3 D syndrome, or 4 Ds disease.

Detailed explanation-2: -Pellagra is caused by a dietary deficiency of niacin or its precursor, tryptophan. It is clinically characterized by “Three D’s”-dermatitis, diarrhea, and dementia.

Detailed explanation-3: -Severe deficiency of niacin (nicotinic acid) and tryptophan, its dietary precursor, is known to cause pellagra, a condition characterised by dementia, diarrhoea, and dermatitis.

Detailed explanation-4: -Pellagra defines systemic disease as resulting from a marked cellular deficiency of niacin. It is characterized by 4 “D’s": diarrhea, dermatitis, dementia, and death. Diagnosis of pellagra is difficult in the absence of the skin lesions, and is often facilitated by the presence of characteristic ones.